To encourage use of alternative systems of medicines in healthcare delivery and to ensure propagation of research and education in these systems, a separate Department of Indian System of Medicine was established by Delhi Government as a part of Health and family welfare Department in May, 1996. In 2013, it was renamed as Directorate of AYUSH where AYUSH stands for Ayurveda, Yoga and Naturopathy, Unani, Siddha and SOWA-Rigpa and Homoeopathy systems of medicines.

Presently, Directorate of AYUSH is located at Ayurvedic and Unani Tibia College Campus, Karol Bagh, New Delhi. Homoeopathic Wing of directorate of AYUSH functions from CSC-III, I Floor, B Block Preet vihar, Delhi.